Lionsgate Sacrifices ?Abduction? To Test Simultaneous Facebook/DVD Release

When you're in charge of getting people to rent a move like Abduction, with its Metacritic score of 25 and a truly remarkable 4% on Rotten Tomatoes, what can you really do? The answer: whatever the hell you want. Short of stuffing free money into every box, few things could really help this one take off ? so you might as well experiment, right? And experiment they shall. Throwing Abduction to the sharks for the sake of testing their teeth, Lionsgate is releasing the film on DVD and Facebook simultaneously.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/sGRpBME0mgI/

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Romney says U.S. should not negotiate with Taliban (Reuters)

MYRTLE BEACH, South Carolina (Reuters) ? Republican presidential front-runner Mitt Romney said on Monday the United States should not negotiate with the Taliban and he criticized the Obama administration for efforts to broker secret talks with the Afghan insurgents.

Romney, who has won the first two Republican contests in the race to pick a nominee to face Democratic President Barack Obama in November, strongly rejected any sort of talks with the Taliban.

"The right course for America is not to negotiate with the Taliban while the Taliban are killing our soldiers," Romney said during a debate of the five Republican presidential hopefuls ahead of Saturday's South Carolina primary. "The right course is to recognize that they are the enemy of the United States."

Romney said Obama had put the United States in a position of "extraordinary weakness" because he had made a decision based on a political calendar on when to pull U.S. troops out of Afghanistan and because he has even publicly announced the date when the United States would completely withdraw from the country.

"We don't negotiate from a position of weakness as we are pulling our troops out," Romney said. "We should not negotiate with the Taliban. We should defeat the Taliban."

Senior U.S. officials told Reuters last month that the United States had been involved in 10 months of secret dialogue with the Taliban. Officials had said the talks had reached a critical juncture and a Taliban prisoner transfer was possible from the Guantanamo Bay military prison into Afghan government custody.

U.S. officials had said a transfer of prisoners could be one confidence-building measure critical to making progress on a peace deal between the Taliban and the government of Afghan President Hamid Karzai.

But Romney said those negotiations sent the wrong message to the people of Afghanistan.

"Think what it says to the people of Afghanistan ... if they see us, their ally, turning and negotiating with the very people they are going to have to protect their nation from."

If Romney wins the Republican nomination, he will face Obama on Election Day November 6. Obama's record on foreign policy and national security is likely to be one of his strengths, however, because he can point to the killing last year of al Qaeda leader Osama bin Laden as one of his victories.

Source: http://us.rd.yahoo.com/dailynews/rss/obama/*http%3A//news.yahoo.com/s/nm/20120117/pl_nm/us_usa_campaign_taliban

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Wylie W. Vale Jr. dies at 70; researcher helped discover stress hormone

Wylie W. Vale Jr., a professor at the Salk Institute for Biological Studies in La Jolla and an internationally renowned expert on brain hormones who led a team of Salk researchers that discovered the brain hormone that triggers the body's reaction to stress, has died. He was 70.

Vale died unexpectedly in his sleep Jan. 3 while on vacation in Hana on the Hawaiian island of Maui, said his wife, Betty. The cause of death has not been determined.

The Texas-born Vale, who joined the Salk Institute in 1970, became one of the world's leading authorities on peptide hormones and growth factors that provide communication between the brain and endocrine system (the organs that produce the body's hormones).

His research team's landmark discovery came in 1981.

"He cracked one of the most challenging problems of our era: He discovered the brain hormone that serves as the on-off switch to the body's stress response, sometimes called the fight-or-flight response," said Ronald M. Evans, a professor and hormone expert at the Salk Institute.

"This has been the subject of speculation and investigation for more than a hundred years," said Evans, adding that Vale had been working on the problem for about 15.

"There was a big effort to try and find the secret for how the stress response is controlled, but the molecule was elusive, present in vanishingly small amounts," Evans said. "The technological challenge was enormous. This was like trying to climb Mt. Everest in biology."

Vale had earned a doctorate in physiology and biochemistry in 1968 at Baylor College of Medicine in Houston, where he trained in the lab under Roger Guillemin.

After Vale followed Guillemin to the Salk Institute in 1970, they continued to work together on perfecting the technology that led to isolating the first two brain peptides. That work led to Guillemin's becoming one of three American scientists who won the 1977 Nobel Prize in physiology and medicine.

In 1978, Vale struck out on his own, setting up an independent lab at the Salk Institute to continue the hunt for the elusive stress hormone.

After Vale's 1981 breakthrough, "neuropeptide discovery exploded into a whole new field of research, which continues today," Evans said.

"The molecule he isolated was called CRF ? corticotropin releasing factor," Evans said. "It's how the brain controls the production of cortisone from the adrenal gland, which is part of the stress response.

"But the discovery of CRF led to the realization that there was a small family of related neuropeptides that help to control anxiety, depression, anorexia, diabetes and drug abuse."

In 1982, Vale and his team discovered another hormone: the growth hormone releasing factor (GRF), which controls the body's growth. "It was another big advance in completing the puzzle of neuropeptides," Evans said.

Vale and his team discovered more than a dozen neuropeptides and their signaling mechanisms.

Vale co-founded two biotech companies ? Neurocrine Biosciences and Acceleron Pharma ? that have gone on to develop the medical and therapeutic potential of his discoveries.

"There are several drugs currently in the clinic and both are for controlling the stress response, as well as controlling metabolic diseases such as diabetes and heart disease," Evans said.

Another treatment that's in advanced clinical trials controls endometriosis, an inflammatory disease of the ovaries commonly linked to infertility.

Vale, who was born in Houston on July 3, 1941, and earned a bachelor's degree in biology from Rice University in 1964, also was an adjunct professor of medicine at UC San Diego. He was elected to the National Academy of Sciences in 1992.

In addition to his wife of 42 years, Vale is survived by his daughters, Elizabeth Gandhi and Susannah Howieson; his father, Wylie; his brother, Shannon; and a granddaughter.

dennis.mclellan@latimes.com

Source: http://feeds.latimes.com/~r/latimes/news/science/~3/eLWbXO36DsM/la-me-wylie-vale-20120118,0,7810239.story

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'Contraband' takes weekend box office with $28.8M

LOS ANGELES (AP) ? The Mark Wahlberg smuggling drama "Contraband" stole the top spot at box office away from the 3-D rerelease of "Beauty and the Beast" and the musical comedy "Joyful Noise" with a $28.8 million debut haul, while "Mission: Impossible ? Ghost Protocol" earned $14.2 million in its fifth weekend to take third place.

The top 20 movies at U.S. and Canadian theaters Friday through Sunday, followed by distribution studio, gross, number of theater locations, average receipts per location, total gross and number of weeks in release, as compiled Monday by Hollywood.com are:

1. "Contraband," Universal, $28,816,095, 2,863 locations, $10,065 average, $28,816,095, one week.

2. "Beauty and the Beast," Disney, $23,507,000, 2,625 locations, $8,955 average, $23,507,000, one week.

3. "Mission: Impossible ? Ghost Protocol," Paramount, $14,200,000, 3,346 locations, $4,244 average, $189,447,000, five weeks.

4. "Joyful Noise," Warner Bros., $13,785,000, 2,735 locations, $5,040 average, $13,785,000, one week.

5. "Sherlock Holmes: A Game of Shadows," Warner Bros., $10,505,000, 3,155 locations, $3,330 average, $172,105,000, five weeks.

6. "The Devil Inside," Paramount Insurge, $9,175,000, 2,551 locations, $3,597 average, $47,522,000, two weeks.

7. "The Girl With the Dragon Tattoo," Sony, $8,100,000, 2,674 locations, $3,029 average, $89,281,000, four weeks.

8. "Alvin and the Chipmunks: Chipwrecked," Fox, $7,825,000, 2,849 locations, $2,747 average, $120,806,288, five weeks.

9. "War Horse," Disney, $7,166,000, 2,856 locations, $2,509 average, $67,338,000, four weeks.

10. "We Bought a Zoo," Fox, $6,800,000, 2,909 locations, $2,338 average, $65,288,534, four weeks.

11. "The Iron Lady," Weinstein Co., $6,474,000, 802 locations, $8,072 average, $7,061,621, three weeks.

12. "The Adventures of Tintin," Paramount, $5,225,000, 2,073 locations, $2,521 average, $68,930,000, four weeks.

13. "Tinker Tailor Soldier Spy," Focus, $3,800,000, 886 locations, $4,289 average, $15,742,540, six weeks.

14. "The Descendants," Fox Searchlight, $2,530,000, 660 locations, $3,833 average, $47,534,196, nine weeks.

15. "The Artist," Weinstein Co., $1,470,000, 216 locations, $6,806 average, $9,066,779, eight weeks.

16. "Hugo," Paramount, $1,325,000, 545 locations, $2,431 average, $54,442,000, eight weeks.

17. "New Year's Eve," Warner Bros., $1,275,000, 1,092 locations, $1,168 average, $53,929,000, six weeks.

18. "The Darkest Hour," Summit, $1,265,000, 1,182 locations, $1,070 average, $20,714,174, four weeks.

19. "The Twilight Saga: Breaking Dawn ? Part 1," Summit, $942,000, 708 locations, $1,331 average, $279,811,685, nine weeks.

20. "Carnage," Sony Pictures Classics, $904,567, 494 locations, $1,831 average, $1,491,032, five weeks.

___

Online:

http://www.hollywood.com

___

Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-01-16-Box%20Office/id-245e043e3be84a04bb1c4ed7ff266525

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Video: Dolly dishes what she's been up to

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Automotive swap meet set for Jan. 22 in Canby | OregonLive.com

CANBY ? People can buy, sell and/or trade anything automotive from 8 a.m. to 1 p.m. Jan. 22 at the Clackamas County Fair and Event Center.

Browse the car corral or search for a needed part or accessory from a variety of vendors at the fourth annual Canby Automotive Swap at 694 N.E. Fourth Ave. Admission is $3. Parking is free.

Those interested in renting a vendor or corral space, which start at $20, should visit www.clackamascountyeventcenter.com, call 503-266-1136, or send an email to ccf@wavecable.com.

-- Vickie Kavanagh; 503-294-5913

Source: http://www.oregonlive.com/clackamascounty/index.ssf/2012/01/automotive_swap_meet_set_for_j_1.html

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